A new study has found that high blood pressure is casually associated with the most common heart rhythm disorder.
The findings of the study were published in the ‘European Journal of Preventive Cardiology’.
Study author Dr Georgios Georgiopoulos of King’s College London, UK and National and Kapodistrian University of Athens, Greece said, “Establishing that elevated blood pressure causes atrial fibrillation provides further impetus for public health strategies aimed at improving blood pressure control in the general population and for individual efforts to keep levels in check.”
Atrial fibrillation is the most common heart rhythm disorder, affecting more than 40 million individuals globally. People with the disorder have a five times greater risk of having a stroke. Previous studies have shown an association between high blood pressure and developing atrial fibrillation, but there was no strong evidence of direct causality.
To investigate whether blood pressure has a direct impact on the risk of atrial fibrillation, the researchers conducted a naturally randomised controlled trial – called Mendelian randomisation. They used data from the largest genome-wide association study (GWAS) on blood pressure and atrial fibrillation which included more than one million individuals of European ancestry – of which 60,620 had atrial fibrillation and 970,216 did not.
The first step was to identify 894 genetic variants associated with blood pressure. Next, the researchers analysed which of those variants play a role in atrial fibrillation. To conduct the naturally randomised controlled trial, the 894 genetic variants were randomly allocated to all participants at conception, giving each individual a blood pressure level. The investigators then analysed the association between blood pressure and atrial fibrillation.
